Compile Data Set for Download or QSAR

Found 160 hits for UniProtKB: Q9Y698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311805 (7-(4-Fluorophenyl)-8-(7-chloro-1H-indazol-5-yl)-2-...) Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C20H10ClF4N5/c21-15-8-11(7-12-9-26-28-17(12)15)16-14(10-1-3-13(22)4-2-10)5-6-30-18(16)27-19(29-30)20(23,24)25/h1-9H,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311771 (2-Cyclopentyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H22FN5/c1-15-12-18(13-19-14-27-29-23(15)19)22-21(16-6-8-20(26)9-7-16)10-11-31-25(22)28-24(30-31)17-4-2-3-5-17/h6-14,17H,2-5H2,1H3,(H,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292056 (2-Cyclobutyl-3-(7-methyl-1H-indazol-5-yl)-5-(trifl...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1 Show InChI InChI=1S/C19H16F3N5/c1-10-7-11(8-12-9-23-25-16(10)12)18-17-14(26-27(18)13-3-2-4-13)5-6-15(24-17)19(20,21)22/h5-9,13H,2-4H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292057 (3-(7-Chloro-1H-indazol-5-yl)-2-cyclobutyl-5-(trifl...) Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc(Cl)c4[nH]ncc4c3)c2n1 Show InChI InChI=1S/C18H13ClF3N5/c19-12-7-9(6-10-8-23-25-15(10)12)17-16-13(26-27(17)11-2-1-3-11)4-5-14(24-16)18(20,21)22/h4-8,11H,1-3H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311848 (8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...) Show SMILES CC(C)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4/c1-9(2)14-8-26-4-3-12(18(20,21)22)15(17(26)24-14)10-5-11-7-23-25-16(11)13(19)6-10/h3-9H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311766 (2-Cyclobutyl-7-(4-fluorophenyl)-8-(7-methyl-1H-ind...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H20FN5/c1-14-11-17(12-18-13-26-28-22(14)18)21-20(15-5-7-19(25)8-6-15)9-10-30-24(21)27-23(29-30)16-3-2-4-16/h5-13,16H,2-4H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311811 (7-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-2-(triflu...) Show SMILES CC(C)c1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C18H16F3N5/c1-9(2)13-4-5-26-16(23-17(25-26)18(19,20)21)14(13)11-6-10(3)15-12(7-11)8-22-24-15/h4-9H,1-3H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292055 (7-Chloro-5-(2-cyclobutyl-5-(trifluoromethyl)-2H-py...) Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1 Show InChI InChI=1S/C19H14ClF3N4O/c20-12-7-10(6-9-8-15(28)25-16(9)12)18-17-13(26-27(18)11-2-1-3-11)4-5-14(24-17)19(21,22)23/h4-7,11H,1-3,8H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311808 (2-(Difluoromethyl)-7-(4-fluorophenyl)-8-(7-methyl-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H14F3N5/c1-11-8-13(9-14-10-25-27-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-29-21(17)26-20(28-29)19(23)24/h2-10,19H,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311806 (7-(4-Fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H13F4N5/c1-11-8-13(9-14-10-26-28-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-30-19(17)27-20(29-30)21(23,24)25/h2-10H,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292054 (5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1 Show InChI InChI=1S/C20H17F3N4O/c1-10-7-12(8-11-9-16(28)25-17(10)11)19-18-14(26-27(19)13-3-2-4-13)5-6-15(24-18)20(21,22)23/h5-8,13H,2-4,9H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311847 (5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...) Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4/c17-10-4-7(3-8-5-24-26-13(8)10)12-9(15(18,19)20)1-2-27-6-11(16(21,22)23)25-14(12)27/h1-6H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292053 (3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-5-(triflu...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)26-16(9-5-10-7-22-24-14(10)11(18)6-9)15-12(25-26)3-4-13(23-15)17(19,20)21/h3-8H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311810 (2-Cyclopropyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H18FN5/c1-13-10-16(11-17-12-25-27-21(13)17)20-19(14-4-6-18(24)7-5-14)8-9-29-23(20)26-22(28-29)15-2-3-15/h4-12,15H,2-3H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311768 (7-Cyclopentyl-8-(7-methyl-1H-indazol-5-yl)-2-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C1CCCC1 Show InChI InChI=1S/C20H18F3N5/c1-11-8-13(9-14-10-24-26-17(11)14)16-15(12-4-2-3-5-12)6-7-28-18(16)25-19(27-28)20(21,22)23/h6-10,12H,2-5H2,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM426135 (5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...) Show SMILES FC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)29-20)32-12-9-28-24(25(32)30-22)31-10-7-19(27)8-11-31/h1-6,9,12-13,19H,7-8,10-11,14H2,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...				ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311849 (2-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(triflu...) Show SMILES CC(C)c1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C19H17F3N4/c1-10(2)15-9-26-5-4-14(19(20,21)22)16(18(26)24-15)12-6-11(3)17-13(7-12)8-23-25-17/h4-10H,1-3H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM426135 (5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...) Show SMILES FC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)29-20)32-12-9-28-24(25(32)30-22)31-10-7-19(27)8-11-31/h1-6,9,12-13,19H,7-8,10-11,14H2,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...				ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311828 (8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...) Show SMILES CC(C)c1cn2cnc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)12-6-26-7-22-15(17(19,20)21)13(16(26)24-12)9-3-10-5-23-25-14(10)11(18)4-9/h3-8H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292061 (5-(Difluoromethyl)-2-isopropyl-3-(7-methyl-1H-inda...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F Show InChI InChI=1S/C18H17F2N5/c1-9(2)25-17(11-6-10(3)15-12(7-11)8-21-23-15)16-13(24-25)4-5-14(22-16)18(19)20/h4-9,18H,1-3H3,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292037 (2-Cyclopentyl-3-(7-methyl-1H-indazol-5-yl)-5-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCCC1 Show InChI InChI=1S/C20H18F3N5/c1-11-8-12(9-13-10-24-26-17(11)13)19-18-15(6-7-16(25-18)20(21,22)23)27-28(19)14-4-2-3-5-14/h6-10,14H,2-5H2,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311829 (8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-7-(trif...) Show SMILES FC(F)(F)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C17H11ClF3N5/c18-11-4-9(3-10-5-23-25-14(10)11)13-15(17(19,20)21)22-7-26-6-12(8-1-2-8)24-16(13)26/h3-8H,1-2H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311799 (8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...) Show SMILES CC(C)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)15-23-16-13(11(17(19,20)21)3-4-26(16)25-15)9-5-10-7-22-24-14(10)12(18)6-9/h3-8H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311843 (3-Chloro-8-(7-chloro-1H-indazol-5-yl)-2-cyclopropy...) Show SMILES FC(F)(F)c1ncn2c(Cl)c(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C17H10Cl2F3N5/c18-10-4-8(3-9-5-24-26-12(9)10)11-14(17(20,21)22)23-6-27-15(19)13(7-1-2-7)25-16(11)27/h3-7H,1-2H2,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311833 (8-(7-Chloro-1H-indazol-5-yl)-7-isopropyl-2-(triflu...) Show SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)14-13(9-3-10-5-23-25-15(10)11(18)4-9)16-24-12(17(19,20)21)6-26(16)7-22-14/h3-8H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311845 (5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...) Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1)C(F)(F)F Show InChI InChI=1S/C17H8ClF6N3O/c18-10-4-7(3-8-5-12(28)26-14(8)10)13-9(16(19,20)21)1-2-27-6-11(17(22,23)24)25-15(13)27/h1-4,6H,5H2,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311792 (8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-7-(trif...) Show SMILES FC(F)(F)c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C17H11ClF3N5/c18-12-6-9(5-10-7-22-24-14(10)12)13-11(17(19,20)21)3-4-26-16(13)23-15(25-26)8-1-2-8/h3-8H,1-2H2,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292065 (5,7-Bis(difluoromethyl)-2-isopropyl-3-(7-methyl-1H...) Show SMILES CC(C)n1nc2c(cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F)C(F)F Show InChI InChI=1S/C19H17F4N5/c1-8(2)28-17(10-4-9(3)14-11(5-10)7-24-26-14)16-15(27-28)12(18(20)21)6-13(25-16)19(22)23/h4-8,18-19H,1-3H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM426226 (5-[2-(4-Fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyr...) Show SMILES OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O2/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)28-20)21-7-10-27-25(31(21)29-24)30-11-8-19(32)9-12-30/h1-7,10,13,19,32H,8-9,11-12,14H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...				ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311793 (2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F3N5/c1-9-6-11(7-12-8-22-24-15(9)12)14-13(18(19,20)21)4-5-26-17(14)23-16(25-26)10-2-3-10/h4-8,10H,2-3H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311781 (8-(7-Chloro-1H-indazol-5-yl)-2,7-bis(trifluorometh...) Show SMILES FC(F)(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F Show InChI InChI=1S/C15H6ClF6N5/c16-9-4-6(3-7-5-23-25-11(7)9)10-8(14(17,18)19)1-2-27-12(10)24-13(26-27)15(20,21)22/h1-5H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311767 (6-(7-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...) Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F Show InChI InChI=1S/C20H10F4N4OS/c21-12-4-1-10(2-5-12)13-7-8-28-17(26-18(27-28)20(22,23)24)16(13)11-3-6-14-15(9-11)30-19(29)25-14/h1-9H,(H,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292052 (2-Isopropyl-3-(7-methyl-1H-indazol-5-yl)-5-(triflu...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C18H16F3N5/c1-9(2)26-17(11-6-10(3)15-12(7-11)8-22-24-15)16-13(25-26)4-5-14(23-16)18(19,20)21/h4-9H,1-3H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292051 (7-Chloro-5-(2-isopropyl-5-(trifluoromethyl)-2H-pyr...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4O/c1-8(2)26-17(10-5-9-7-14(27)24-15(9)11(19)6-10)16-12(25-26)3-4-13(23-16)18(20,21)22/h3-6,8H,7H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311850 (2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-6-12(7-13-8-23-25-17(10)13)16-14(19(20,21)22)4-5-26-9-15(11-2-3-11)24-18(16)26/h4-9,11H,2-3H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311830 (2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ncn2cc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F3N5/c1-9-4-11(5-12-6-23-25-15(9)12)14-16(18(19,20)21)22-8-26-7-13(10-2-3-10)24-17(14)26/h4-8,10H,2-3H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM426232 (5-[7-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)py...) Show SMILES CC(=O)N1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H23FN6O2/c1-16(34)31-10-12-32(13-11-31)26-28-9-8-22-24(18-4-7-21-19(14-18)15-23(35)29-21)25(30-33(22)26)17-2-5-20(27)6-3-17/h2-9,14H,10-13,15H2,1H3,(H,29,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...				ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292045 (3-(7-Chloro-1H-indazol-5-yl)-2-methyl-5-(trifluoro...) Show SMILES Cn1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C15H9ClF3N5/c1-24-14(7-4-8-6-20-22-12(8)9(16)5-7)13-10(23-24)2-3-11(21-13)15(17,18)19/h2-6H,1H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311844 (8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-3-fluor...) Show SMILES Fc1c(nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn12)C(F)(F)F)C1CC1 Show InChI InChI=1S/C17H10ClF4N5/c18-10-4-8(3-9-5-24-26-12(9)10)11-14(17(20,21)22)23-6-27-15(19)13(7-1-2-7)25-16(11)27/h3-7H,1-2H2,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311769 (7-(Azetidin-1-yl)-8-(7-methyl-1H-indazol-5-yl)-2-(...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)N1CCC1 Show InChI InChI=1S/C18H15F3N6/c1-10-7-11(8-12-9-22-24-15(10)12)14-13(26-4-2-5-26)3-6-27-16(14)23-17(25-27)18(19,20)21/h3,6-9H,2,4-5H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311834 (8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...) Show SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F Show InChI InChI=1S/C17H14ClF2N5/c1-8(2)14-13(9-3-10-5-22-24-15(10)11(18)4-9)17-23-12(16(19)20)6-25(17)7-21-14/h3-8,16H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311783 (5-(2,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...) Show SMILES FC(F)(F)c1nc2c(-c3cc4CC(=O)Nc4c(Cl)c3)c(ccn2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4O/c17-9-4-6(3-7-5-10(28)24-12(7)9)11-8(15(18,19)20)1-2-27-13(11)25-14(26-27)16(21,22)23/h1-4H,5H2,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311775 (8-(7-Chloro-1H-indazol-5-yl)-2,7-bis(trifluorometh...) Show SMILES FC(F)(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn2n1)C(F)(F)F Show InChI InChI=1S/C14H5ClF6N6/c15-7-2-5(1-6-3-23-25-9(6)7)8-10(13(16,17)18)22-4-27-11(8)24-12(26-27)14(19,20)21/h1-4H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311831 (7-Chloro-5-[2-cyclopropyl-7-(trifluoromethyl)imida...) Show SMILES FC(F)(F)c1ncn2cc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4O/c19-11-4-9(3-10-5-13(27)25-15(10)11)14-16(18(20,21)22)23-7-26-6-12(8-1-2-8)24-17(14)26/h3-4,6-8H,1-2,5H2,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311754 (8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...) Show SMILES FC(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)10-8(15(19,20)21)1-2-26-14(10)23-13(25-26)12(17)18/h1-5,12H,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311824 (5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C17H10F6N4/c1-8-4-9(5-10-6-24-26-14(8)10)13-11(16(18,19)20)2-3-27-7-12(17(21,22)23)25-15(13)27/h2-7H,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311846 (5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H11F6N3O/c1-8-4-9(5-10-6-13(28)26-15(8)10)14-11(17(19,20)21)2-3-27-7-12(18(22,23)24)25-16(14)27/h2-5,7H,6H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292049 (3-(7-Chloro-1H-indazol-5-yl)-2-ethyl-5-(trifluorom...) Show SMILES CCn1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C16H11ClF3N5/c1-2-25-15(8-5-9-7-21-23-13(9)10(17)6-8)14-11(24-25)3-4-12(22-14)16(18,19)20/h3-7H,2H2,1H3,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.398	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292050 (5-(2-Isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F Show InChI InChI=1S/C19H17F3N4O/c1-9(2)26-18(12-6-10(3)16-11(7-12)8-15(27)24-16)17-13(25-26)4-5-14(23-17)19(20,21)22/h4-7,9H,8H2,1-3H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.398	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311851 (2-Ethyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluorom...) Show SMILES CCc1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4/c1-3-13-9-25-5-4-14(18(19,20)21)15(17(25)23-13)11-6-10(2)16-12(7-11)8-22-24-16/h4-9H,3H2,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair

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